| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Cycloserine | Eli Lilly & Co. | Statim Pharmaceuticals Ltd | 250mg | 100 | Tablet | per tablet | KES 23,252.00 |
| Cycloserine More info | |
|---|---|
| Mode Of Action | Cycloserine, an analog of the amino acid D-alanine, interferes with bacterial cell wall synthesis by competitive inhibition of two enzymes, L-alanine racemase, which forms D-alanine from L-alanine, and D-alanylalanine synthetase. these enzymes are involved in the incorporation of D-alanine into the pentapeptide necessary for peptidoglycan formation and bacterial cell wall synthesis. |
| Drug Indication | Multi-drug resistant TB. |
| Precautions | Obtain cultures and determine susceptibility before treatment, monitor haematological, renal and hepatic parameters. |
| Contra-Indications | Epileptic convulsions, hypersensitivity to cycloserine, excessive alcohol. |
| Side Effects | Convulsions, vertigo, drowsiness, headache, suicidal tendencies, character changes, hypersensitivity reactions. |
| Dosage | Initially 250mg every 12 hours for 2 weeks increased according to blood concentration and response to max. 500mg every 12 hours; child initially 10mg/kg daily adjusted according to blood concentration and response. |
| Pregnancy Category | Category C |
| Pregnancy Category Description | Drugs which, owing to their pharmacological effects, or may be suspected of causing detrimental effects on human foetus or neonates without causing malfunctions. These effects may be reversible |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Anti-Tuberculous Drugs |